The object of our study of the functional activity of the body's immune reactions over a long period (2021–2024) was Pelophylax ridibundus in the reservoir of an urbanized territory (Silikatnoye Lake, Nizhny Novgorod) infected with Hepatozoon spp. A hydrochemical analysis of the habitat of P. ridibundus was done. Intraerythrocyte parasites were accounted for with the calculation of the extent and intensity of invasion and abundance of hemoparasites.