Natural polyploidy cases in reptiles are analyzed. They are characterized by spontaneous autotriploidy, non-hybrid mixoploidy (2/3n), hybrid biotypes (2 and 3n), polyploid species, and tetraploid hybrids obtained from crossing triploids with diploids. Polyploid species are always triploid and parthenogenetic. Neither gynogenesis nor various types of hemiclonal inheritance have been observed among them. In all cases studied, reticulate speciation in reptiles stops at the stage associated with tetraploidy.